Non-Watson-Crick base pairs modulate homologous alignments in RecA pairing reactions
نویسندگان
چکیده
منابع مشابه
Non-Watson-Crick base pairs in RNA-protein recognition.
The cellular functions of most RNA molecules involve protein binding, and non-Watson-Crick base pairs are hallmark sites for interactions with proteins. The determination of three-dimensional structures of RNA-peptide and RNA-protein complexes reveals the molecular basis of non-Watson-Crick base-pair recognition.
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Tricyclo-DNA belongs to the family of conformationally restricted oligodeoxynucleotide analogues. It differs structurally from DNA by an additional ethylene bridge between the centers C(3') and C(5') of the nucleosides, to which a cyclopropane unit is fused for further enhancement of structural rigidity. The synthesis of the hitherto unknown tricyclodeoxynucleosides containing the bases cytosin...
متن کاملOn the propeller structure of isolated Watson-Crick base pairs.
The nucleotide sequence dependence of the DNA and RNA secondary structure is a problem of current interest in molecular biophysics. The key role of stacking interactions in determining this dependence is widely accepted [1, 2], It is be lieved that the propeller twisting of base pairs, ob served in the structure of both nucleic acids and crystals of nucleosides and nucleotides is a direct man...
متن کاملMolecular recognition of Watson-Crick-like purine-purine base pairs.
Nucleic acid duplexes containing non-Watson–Crick base pairs are of interest to several fields including structural biology, supramolecular chemistry, origin of life, and synthetic biology. An early observation of a natural non-Watson–Crick base pair was the tRNA–mRNA adenine–inosine wobble pair, and it is now known that purine–purine pairs occur frequently in natural RNAs, including ribosomes ...
متن کاملCharacterization of imperfect DNA duplexes containing unpaired bases and non-Watson-Crick base pairs.
Synthetic duplex DNAs of repeating sequence, such as poly d(TTC).poly d(GAA), were separated into their individual single strands. The various single strands complexed not only, as expected, with their complementary strands, but also with other non-complementary strands. Characterization of such complexes with respect to stoichiometry, Tm values and the dependence of Tm on NaCl concentration sh...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1998
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(98)00195-1